HLA Typing: Choosing the Right Analysis for Your Research

Scientists often contemplate the age-old question of should I use High-Resolution HLA typing or Low-Resolution HLA typing. Here at Avrok we aim to equip you with the information you need to make the decision that is right for you. Let’s delve into the details and understand how each method can benefit your research or clinical needs

High Resolution HLA Typing: Precision at Its Finest

Avrok Biosciences' High Resolution HLA Typing offers comprehensive insights into genetic profiles with the following features:

• Coverage: Examines 11 key loci encompassing both Class I (HLA-A, HLA-B, HLA-C) and Class II genes (HLA-DPA1/DPB1, HLA-DQA1/DQB1, HLA-DRB1/3/4/5).
• Resolution: Provides four-field resolution, pinpointing specific gene variants with detail crucial for precise medical and research applications.
• Technology: Utilizes Next Generation Sequencing (NGS), ensuring robust data quality and accuracy suitable for complex genetic analyses.
• Sample Flexibility: Accepts various sample types including buccal swabs, whole blood, and tissue, accommodating different research and clinical scenarios.
• Turnaround Time: Typically completed within 2 weeks, with expedited options available to meet urgent needs.
• Batch Size Impact: Best pricing is achieved with batch sizes of 20-24 samples, with the flexibility to accommodate smaller batches. This structure optimizes workflow efficiency and cost-effectiveness.

Low Resolution HLA Typing: Flexibility and Efficiency

Avrok Biosciences' Low Resolution HLA Typing offers practical benefits tailored to specific research and clinical requirements:

• Coverage: Includes essential Class I (HLA-A, HLA-B, HLA-C) and Class II genes (HLA-DR, HLA-DQ, HLA-DP), providing a foundational assessment of genetic compatibility.
• Customization: Allows selection of specific loci of interest, offering flexibility in study design and cost-effectiveness by focusing only on relevant genetic markers.
• Technology: Utilizes Real-Time qPCR, a rapid and efficient method suitable for screening purposes and initial assessments.
• Sample Requirements: Accommodates varying DNA inputs depending on the targeted loci, ensuring suitability for diverse sample types such as buccal swabs and cultured cells.
• Turnaround Time: Completed within 1 week on average, with options for expedited processing to meet tight project timelines.
• Batch Size Impact: Minimum batch size is 1 sample, ideal for individualized studies and scenarios where you already have a specific loci of interest. This flexibility supports tailored research needs and ensures efficient processing.

Choosing the Right Approach: Precision vs. Practicality

• For Precision and Depth: High-Resolution HLA Typing excels in detailed genetic analysis, ideal for studies requiring a nuanced understanding of immune responses and disease predispositions.
• For Screening and Initial Assessments: Low-Resolution HLA Typing offers efficiency and flexibility, making it suitable for large-scale population studies, preliminary donor screening, and urgent clinical decisions.

In conclusion, Avrok Biosciences' High Resolution and Low Resolution HLA Typing services cater to diverse needs in research and clinical settings. Whether you seek detailed genetic profiles or efficient screening tools, Avrok Biosciences provides the expertise and technology to advance your genetic studies and enhance patient care.

Explore the possibilities of genetic analysis with Avrok Biosciences and unlock new insights into human health and compatibility.